DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity
نویسندگان
چکیده
منابع مشابه
Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.
Addictive diseases, including addiction to heroin, prescription opioids, or cocaine, pose massive personal and public health costs. Addictions are chronic relapsing diseases of the brain caused by drug-induced direct effects and persisting neuroadaptations at the epigenetic, mRNA, neuropeptide, neurotransmitter, or protein levels. These neuroadaptations, which can be specific to drug type, and ...
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Regulation of gene expression is one mechanism by which drugs of abuse can induce relatively long-lasting changes in the brain to cause a state of addiction. Here, we focus on two transcription factors, CREB (cAMP response element binding protein) and DeltaFosB, which contribute to drug-induced changes in gene expression. Both are activated in the nucleus accumbens, a major brain reward region,...
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Drug addiction represents a pathological form of neuroplasticity along with the emergence of aberrant behaviors involving a cascade of neurochemical changes mainly in the brain's rewarding circuitry. The aberrant behavioral phenotypes can be assessed by an animal model of drug-induced behavioral sensitization, which is characterized by an initiation stage that is formed in the ventral tegmental...
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of a dissertation at the University of Miami. An important target for combating drug addiction is to understand the neurobiological mechanisms that sub-serve relapse to drug use. Drug addiction is thought to usurp the neural mechanisms of learning and memory. The conditioned place preference (CPP) paradigm which employs the principles of Pavlovian learning is often used to investigate the incen...
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The National Institute on Drug Abuse was founded in 1974, and since that time there have been significant advances in understanding the processes by which drugs of abuse cause addiction. The initial protein targets for almost all drugs of abuse are now known. Animal models that replicate key features of addiction are available, and these models have made it possible to characterize the brain re...
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ژورنال
عنوان ژورنال: Neuroscience Research
سال: 2016
ISSN: 0168-0102
DOI: 10.1016/j.neures.2015.09.001